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University Library Research Guides Synthesis Review Synthesis Review Toolkit Introduction All Resources
All Additional Resources
Resources from Stage 1: Getting Started
Step 1: How to Formulate a Research Question
List of several types of question formats used to formulate a research question by the Virginia Commonwealth University
Clear and present questions: formulating questions for evidence based practice: Booth, A. (2006). Library hi tech, 24(3), 355-368.
Beyond PICO: The SPIDER tool for qualitative evidence synthesis: Cooke, A., Smith, D., & Booth, A. (2012). Qualitative Health Research, 22(10), 1435-1443.
Formulating the evidence based practice question: a review of the frameworks: Davies, K. S. (2011). Evidence Based Library and Information Practice, 6(2), 75-80.
Wildridge, V., & Bell, L. (2002). How CLIP became ECLIPSE: a mnemonic to assist in searching for health policy/management information. Health Information & Libraries Journal, 19(2), 113-115.
Step 2: What Type of Review to Conduct
Step 3: Where Can I Find Reviews
Scoping Reviews
Realist Reviews
Ramesesproject.org/ : Realist Review standards and training materials
Realist synthesis: illustrating the method for implementation research. Rycroft-Malone, J., McCormack, B., Hutchinson, A. M., DeCorby, K., Bucknall, T. K., Kent, B., ... & Wallin, L. (2012). Implementation Science, 7(1), 33.
Step 4: Who to Include on the Research Team
Step 5: How to Write/Register a Review Protocol
Synthesising qualitative and quantitative evidence: A review of possible methods. Dixon-Woods, M., Agarwal, S., Jones, D., Young, B., & Sutton, A. (2005). Journal of Health Services Research & Policy,10(1), 45–53.
How can systematic reviews incorporate qualitative research? Dixon-Woods, M., Bonas, S., Booth, A., Jones, D. R., Miller, T., Sutton, A. J., . . . Young, B. (2006). Qualitative Research,6 (1), 27–44.
A mixed-methods approach to systematic reviews. Pearson, A, White, H, Bath-Hextall, F, Salmond, S, Apostolo, J, & Kirkpatrick, P. 2015. International Journal of Evidence-Based Healthcare, 13(3), 121-131.
Rapid Review Guidebook: Steps for Conducting a Rapid Review.The National Collaboration Centre for Methods and Tools.
Methods for the thematic synthesis of qualitative research in systematic reviews. Thomas, J., & Harden, A. (2008). BMC Medical Research Methodology, 8, 45–45.
Meta-synthesis method for qualitative research: a literature review. Walsh, D. and Downe, S. (2005). Journal of Advanced Nursing, 50, 204–211.
Protocol Template: Systematic Review (University of Warwick)
Template for a Systematic Literature Review Protocol (Durham University)
Resources from Stage 2: Developing the Search
Step 1: What to Search
Organizing Terminology
Pubvenn - Website with tool to help you practice boolean logic
Database reference guide - A quick reference page which indicates database-specific information (e.g., truncating in OVID vs CINAHL)
Using text mining for study identification in systematic reviews: a systematic review of current approaches: O’Mara-Eves, A., Thomas, J., McNaught, J., Miwa, M., & Ananiadou, S. (2015). Systematic reviews, 4(1).
Search Filters
Tutorial from Yale on Filters and Hedges
Choosing and using methodological search filters: searchers' views: Beale, S., Duffy, S., Glanville, J., Lefebvre, C., Wright, D., McCool, R., ... & Smith, L. (2014). Health Information & Libraries Journal, 31(2), 133-147.
Reporting methodological search filter performance comparisons: a literature review: Harbour, J., Fraser, C., Lefebvre, C., Glanville, J., Beale, S., Boachie, C., ... & Smith, L. (2014). Health Information & Libraries Journal, 31(3), 176-194.
Retrieving randomized controlled trials from medline: a comparison of 38 published search filters. McKibbon, K. A., Wilczynski, N. L., & Haynes, R. B. (2009). Health Information & Libraries Journal, 26(3), 187-202.
Step 2: Where to Search
Grey Literature
Hand Searching
Searching Trial Registries
Searching ClinicalTrials.gov and the international clinical trials registry platform to inform systematic reviews: What are the optimal search approaches?*: Glanville, J. M., M.Sc, Duffy, S., PgDip, McCool, R., B.Sc, & Varley, D., M.Sc. (2014). Journal of the Medical Library Association, 102(3), 177-83.
Contacting Authors
Step 3: How to Create a Search Strategy
Tools for Finding Syntax and Subject Headings for Common Databases
Validating the Search
PRESS peer review of electronic search strategies: 2015 guideline statement. McGowan, J., Sampson, M., Salzwedel, D. M., Cogo, E., Foerster, V., & Lefebvre, C. (2016). Journal of clinical epidemiology, 75, 40-46.
PRESS – Peer Review of Electronic Search Strategies: 2015 Guideline Explanation and Elaboration (PRESS E&E). Ottawa: CADTH; 2016 Jan.
Action: Run your Search
Search Strategy Example from Scoping Review. From the article: Social media use among patients and caregivers: a scoping review. Hamm, M. et al. (2013). BMJ open, 3 (5), e002819.
Methods for documenting systematic review searches: a discussion of common issues: Rader, T., Mann, M., Stansfield, C., Cooper, C., & Sampson, M. (2014). Research synthesis methods, 5(2), 98-115.
Training for Citation Management Tools
Resources from Stage 3: Screening
Step 1: How to Plan Screening Process
Step 2: How to Screen
Step 3: How to Report Screening Process
PRISMA's Flow Diagram Generator
The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P., ... & Moher, D. (2009). PLoS medicine, 6(7), e1000100.
Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., ... & Stewart, L. A. (2015). Systematic Reviews, 4(1), 1.
The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations: Hutton, B., Salanti, G., Caldwell, D. M., Chaimani, A., Schmid, C. H., Cameron, C., ... & Mulrow, C. (2015). Annals of internal medicine, 162(11), 777-784.
Resources from Stage 4: Extracting Data
Step 1: How to Plan Data Extraction
Cochrane Reviews' Information on Data Extraction: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 6.3 (updated February 2022). Cochrane, 2022. Note: A checklist is provided in Chapter 5 of items to consider in data extraction.
Choice of data extraction tools for systematic reviews depends on resources and review complexity: Elamin, M. B. et al. (2009). Journal of clinical epidemiology, 62(5), 506-510.
Data extraction forms that may be able to be adapted to your review (provided by the University of Ottawa):
Resources from Stage 5: Evaluating Data
Step 1: How to Identify Appraisal Criteria
Step 2: How to Assess Quality of Included Studies
Step 3: Assessing the Confidence in Cumulative Evidence
GRADE Resources (from Cochrane; Handbook, software, introduction to using GRADE, common errors in GRADE)
GRADE-CERQual: An introduction for qualitative evidence synthesis [Cochrane webinar)
GRADE-CERQual: Applying GRADE-CERQual to qualitative evidence synthesis findings–paper 6: how to assess relevance of the data. Noyes, J., Booth, A., Lewin, S., Carlsen, B., Glenton, C., Colvin, C. J., ... & Tunςalp, Ö. (2018). Implementation Science, 13(1), 4.
GRADE provides guidance for rating the quality of evidence and the strength of recommendations in health care. A series of articles describing the GRADE approach were published in the Journal of Clinical Epidemiology (2011, Vol 64, Issue 4).
GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables
GRADE guidelines: 2. Framing the question and deciding on important outcomes
GRADE guidelines: 3. Rating the quality of evidence
GRADE guidelines: 4. Rating the quality of evidence—study limitations (risk of bias)
GRADE guidelines: 5. Rating the quality of evidence—publication bias
GRADE guidelines 6. Rating the quality of evidence—imprecision
GRADE guidelines: 7. Rating the quality of evidence—inconsistency
GRADE guidelines: 8. Rating the quality of evidence—indirectness
Resources from Stage 6: Analysis & Synthesis
Step 1:
Cochrane Handbook, Chapter 10 "Analyzing data and undertaking meta-analyses"
Realist Synthesis, Rameses Training Materials (July 2013) by G Wong, G. Westthorp, R. Pawson & T. Greenhalgh. See Section 7.
Scoping studies: advancing the methodology. Levac, D., Colquhoun, H., & O'Brien, K. K. (2010). Implementation science, 5(1), 69.
All Resources from Stage 7: Writing & Publishing your Review
Step 1: How to Write your Review
Reporting standards:
Step 2: How to Publish your Review
Open Access Repositories by Discipline
Full-publications
Preprints
Step 3: Where to Promote your Research
From the Wiley Network Blog: