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Clinical Medicine: Perioperative Care



Link to Chest Guidelines 2012.



Mangano DT, et al. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. NEJM 1996; 335(23): 1713-1801.

Lindenauer et al. Perioperative Beta-Bocker Therapy and Mortality after Major Noncardiac Surgery. N Engl J Med 2005; 353: 349-61.

POISE Study Group. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomized controlled trial.

Dunkelgrun et al. Bisoprolol and Fluvastatin for the Reduction of Perioperative Cardiac Mortality and Myocardial Infarction in Intermediate-Risk Patients Undergoing Noncardiovascular Surgery. A Randomized Controlled Trial (DECREASE-IV). Ann Surg 2009; 249: 921-926.

Juul et al. Effect of perioperative β blockade in patients with diabetes undergoing major non-cardiac surgery: randomized placebo controlled, blinded multicentre trial. BMJ 2006; 332(7556): 1482.

Yang et al. The effects of perioperative β-blockaged: Results of the Metoprolol after Vascular Sugery (MaVS) study, a randomized controlled trial. Am Heart J 2006; 152:983-90.


Biologics and Arthritis

Mushtaq S, Goodman SM, Scanzello CR. Perioperative management of biologic agents used in treatment of rheumatoid arthritis.   Am J Ther [Internet]. 2011;18(5):426-34.




Schouten et al. Fluvastatin and Perioperative Events in Patients Undergoing Vascular Surgery. N Engl J Med 2009; 361:980-9.

Redelmeier DA, Thiruchelvam D, Daneman N. Delirium after elective surgery among elderly patients taking statins. CMAJ 2009; 179(7):645-52.

Rosenman et al. Clinical Consequences of Withholding Versus Administering Renin-Angiotensin-Aldosterone System Antagonists in the Preoperative Period. Journal of Hospital Medicine 2008; 3:319-325.

Effect of perioperative statins on death, myocardial infarction, atrial fibrillation, and length of stay: a systematic review and meta-analysis. Arch Surg. 2012 Feb;147(2):181-9.

Risk of intraoperative hypotension with loop diuretics: a randomized controlled trial. Khan NA, Campbell NR, Frost SD, Gilbert K, Michota FA, Usmani A, Seal D, Ghali WA. Am J Med. 2010 Nov;123(11):1059.e1-8



Marik PE and Varon J. Requirement of Perioperative Stress Doses of Corticosteroids. A Systematic Review of the Literature. Arch Surg. 2008; 143(12): 1222-1226.